diff --git a/domains/health/loneliness-independently-increases-dementia-risk-19-31-percent-after-depression-adjustment-with-vascular-dementia-showing-strongest-association.md b/domains/health/loneliness-independently-increases-dementia-risk-19-31-percent-after-depression-adjustment-with-vascular-dementia-showing-strongest-association.md index 2b5bd2f6c..1d349ebfb 100644 --- a/domains/health/loneliness-independently-increases-dementia-risk-19-31-percent-after-depression-adjustment-with-vascular-dementia-showing-strongest-association.md +++ b/domains/health/loneliness-independently-increases-dementia-risk-19-31-percent-after-depression-adjustment-with-vascular-dementia-showing-strongest-association.md @@ -1,10 +1,5 @@ ```markdown -## The Claim (current version) - - ## Challenging Evidence - **Source:** PMC12726400, Burden of Proof study group, 2025 - Burden of Proof methodology analysis of 41 studies found mean RR 1.29 (95% UI 0.98–1.71) for social isolation and dementia — confidence interval crosses 1.0, indicating 'possible but uncertain' association. Only 'lack of social activity' sub-measure showed CI not crossing null (mean RR 1.34, 95% UI 1.05–1.71). BoP methodology specifically corrects for publication bias and systematic biases that inflate observational estimates, producing more conservative effect estimates than standard meta-analyses. ``` \ No newline at end of file