reweave: merge 21 files via frontmatter union [auto]
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21 changed files with 94 additions and 11 deletions
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@ -21,6 +21,7 @@ reweave_edges:
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-11'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-11'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-12'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-12'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-13'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-13'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-14'}
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# Autonomous weapons systems capable of militarily effective targeting decisions cannot satisfy IHL requirements of distinction, proportionality, and precaution, making sufficiently capable autonomous weapons potentially illegal under existing international law without requiring new treaty text
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# Autonomous weapons systems capable of militarily effective targeting decisions cannot satisfy IHL requirements of distinction, proportionality, and precaution, making sufficiently capable autonomous weapons potentially illegal under existing international law without requiring new treaty text
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@ -19,6 +19,7 @@ reweave_edges:
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-11'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-11'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-12'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-12'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|related|2026-04-13'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|related|2026-04-13'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck|supports|2026-04-14'}
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supports:
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supports:
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck'}
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- {'Legal scholars and AI alignment researchers independently converged on the same core problem': 'AI cannot implement human value judgments reliably, as evidenced by IHL proportionality requirements and alignment specification challenges both identifying irreducible human judgment as the bottleneck'}
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@ -10,6 +10,14 @@ agent: vida
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scope: causal
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scope: causal
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sourcer: Frontiers in Medicine
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sourcer: Frontiers in Medicine
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related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
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related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
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supports:
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- AI-induced deskilling follows a consistent cross-specialty pattern where AI assistance improves performance while present but creates cognitive dependency that degrades performance when AI is unavailable
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- Dopaminergic reinforcement of AI-assisted success creates motivational entrenchment that makes deskilling a behavioral incentive problem, not just a training design problem
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- Never-skilling — the failure to acquire foundational clinical competencies because AI was present during training — poses a detection-resistant, potentially unrecoverable threat to medical education that is structurally worse than deskilling
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reweave_edges:
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- AI-induced deskilling follows a consistent cross-specialty pattern where AI assistance improves performance while present but creates cognitive dependency that degrades performance when AI is unavailable|supports|2026-04-14
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- Dopaminergic reinforcement of AI-assisted success creates motivational entrenchment that makes deskilling a behavioral incentive problem, not just a training design problem|supports|2026-04-14
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- Never-skilling — the failure to acquire foundational clinical competencies because AI was present during training — poses a detection-resistant, potentially unrecoverable threat to medical education that is structurally worse than deskilling|supports|2026-04-14
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# AI assistance may produce neurologically-grounded, partially irreversible skill degradation through three concurrent mechanisms: prefrontal disengagement, hippocampal memory formation reduction, and dopaminergic reinforcement of AI reliance
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# AI assistance may produce neurologically-grounded, partially irreversible skill degradation through three concurrent mechanisms: prefrontal disengagement, hippocampal memory formation reduction, and dopaminergic reinforcement of AI reliance
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@ -10,6 +10,15 @@ agent: vida
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scope: causal
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scope: causal
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sourcer: Natali et al.
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sourcer: Natali et al.
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related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
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related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
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supports:
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- {'AI assistance may produce neurologically-grounded, partially irreversible skill degradation through three concurrent mechanisms': 'prefrontal disengagement, hippocampal memory formation reduction, and dopaminergic reinforcement of AI reliance'}
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- Dopaminergic reinforcement of AI-assisted success creates motivational entrenchment that makes deskilling a behavioral incentive problem, not just a training design problem
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related:
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- Automation bias in medical imaging causes clinicians to anchor on AI output rather than conducting independent reads, increasing false-positive rates by up to 12 percent even among experienced readers
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reweave_edges:
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- {'AI assistance may produce neurologically-grounded, partially irreversible skill degradation through three concurrent mechanisms': 'prefrontal disengagement, hippocampal memory formation reduction, and dopaminergic reinforcement of AI reliance|supports|2026-04-14'}
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- Automation bias in medical imaging causes clinicians to anchor on AI output rather than conducting independent reads, increasing false-positive rates by up to 12 percent even among experienced readers|related|2026-04-14
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- Dopaminergic reinforcement of AI-assisted success creates motivational entrenchment that makes deskilling a behavioral incentive problem, not just a training design problem|supports|2026-04-14
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# AI-induced deskilling follows a consistent cross-specialty pattern where AI assistance improves performance while present but creates cognitive dependency that degrades performance when AI is unavailable
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# AI-induced deskilling follows a consistent cross-specialty pattern where AI assistance improves performance while present but creates cognitive dependency that degrades performance when AI is unavailable
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@ -12,8 +12,16 @@ sourcer: Artificial Intelligence Review (Springer Nature)
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related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
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related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
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supports:
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supports:
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- Never-skilling in clinical AI is structurally invisible because it lacks a pre-AI baseline for comparison, requiring prospective competency assessment before AI exposure to detect
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- Never-skilling in clinical AI is structurally invisible because it lacks a pre-AI baseline for comparison, requiring prospective competency assessment before AI exposure to detect
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- {'AI assistance may produce neurologically-grounded, partially irreversible skill degradation through three concurrent mechanisms': 'prefrontal disengagement, hippocampal memory formation reduction, and dopaminergic reinforcement of AI reliance'}
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- AI-induced deskilling follows a consistent cross-specialty pattern where AI assistance improves performance while present but creates cognitive dependency that degrades performance when AI is unavailable
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- Automation bias in medical imaging causes clinicians to anchor on AI output rather than conducting independent reads, increasing false-positive rates by up to 12 percent even among experienced readers
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- Never-skilling — the failure to acquire foundational clinical competencies because AI was present during training — poses a detection-resistant, potentially unrecoverable threat to medical education that is structurally worse than deskilling
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reweave_edges:
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reweave_edges:
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- Never-skilling in clinical AI is structurally invisible because it lacks a pre-AI baseline for comparison, requiring prospective competency assessment before AI exposure to detect|supports|2026-04-12
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- Never-skilling in clinical AI is structurally invisible because it lacks a pre-AI baseline for comparison, requiring prospective competency assessment before AI exposure to detect|supports|2026-04-12
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- {'AI assistance may produce neurologically-grounded, partially irreversible skill degradation through three concurrent mechanisms': 'prefrontal disengagement, hippocampal memory formation reduction, and dopaminergic reinforcement of AI reliance|supports|2026-04-14'}
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- AI-induced deskilling follows a consistent cross-specialty pattern where AI assistance improves performance while present but creates cognitive dependency that degrades performance when AI is unavailable|supports|2026-04-14
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- Automation bias in medical imaging causes clinicians to anchor on AI output rather than conducting independent reads, increasing false-positive rates by up to 12 percent even among experienced readers|supports|2026-04-14
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- Never-skilling — the failure to acquire foundational clinical competencies because AI was present during training — poses a detection-resistant, potentially unrecoverable threat to medical education that is structurally worse than deskilling|supports|2026-04-14
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# Clinical AI introduces three distinct skill failure modes — deskilling (existing expertise lost through disuse), mis-skilling (AI errors adopted as correct), and never-skilling (foundational competence never acquired) — requiring distinct mitigation strategies for each
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# Clinical AI introduces three distinct skill failure modes — deskilling (existing expertise lost through disuse), mis-skilling (AI errors adopted as correct), and never-skilling (foundational competence never acquired) — requiring distinct mitigation strategies for each
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@ -9,6 +9,10 @@ title: Comprehensive behavioral wraparound may enable durable weight maintenance
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agent: vida
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agent: vida
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scope: causal
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scope: causal
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sourcer: Omada Health
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sourcer: Omada Health
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related:
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- Digital behavioral support combined with individualized GLP-1 dosing achieves clinical trial weight-loss outcomes with approximately half the standard drug dose
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reweave_edges:
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- Digital behavioral support combined with individualized GLP-1 dosing achieves clinical trial weight-loss outcomes with approximately half the standard drug dose|related|2026-04-14
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# Comprehensive behavioral wraparound may enable durable weight maintenance post-GLP-1 cessation, challenging the unconditional continuous-delivery requirement
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# Comprehensive behavioral wraparound may enable durable weight maintenance post-GLP-1 cessation, challenging the unconditional continuous-delivery requirement
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@ -10,6 +10,10 @@ agent: vida
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scope: causal
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scope: causal
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sourcer: HealthVerity / Danish cohort investigators
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sourcer: HealthVerity / Danish cohort investigators
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related_claims: ["[[GLP-1 receptor agonists are the largest therapeutic category launch in pharmaceutical history but their chronic use model makes the net cost impact inflationary through 2035]]", "[[healthcares defensible layer is where atoms become bits because physical-to-digital conversion generates the data that powers AI care while building patient trust that software alone cannot create]]"]
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related_claims: ["[[GLP-1 receptor agonists are the largest therapeutic category launch in pharmaceutical history but their chronic use model makes the net cost impact inflationary through 2035]]", "[[healthcares defensible layer is where atoms become bits because physical-to-digital conversion generates the data that powers AI care while building patient trust that software alone cannot create]]"]
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supports:
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- Comprehensive behavioral wraparound may enable durable weight maintenance post-GLP-1 cessation, challenging the unconditional continuous-delivery requirement
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reweave_edges:
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- Comprehensive behavioral wraparound may enable durable weight maintenance post-GLP-1 cessation, challenging the unconditional continuous-delivery requirement|supports|2026-04-14
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# Digital behavioral support combined with individualized GLP-1 dosing achieves clinical trial weight-loss outcomes with approximately half the standard drug dose
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# Digital behavioral support combined with individualized GLP-1 dosing achieves clinical trial weight-loss outcomes with approximately half the standard drug dose
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@ -10,6 +10,10 @@ agent: vida
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scope: causal
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scope: causal
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sourcer: Frontiers in Medicine
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sourcer: Frontiers in Medicine
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related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
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related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
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supports:
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- {'AI assistance may produce neurologically-grounded, partially irreversible skill degradation through three concurrent mechanisms': 'prefrontal disengagement, hippocampal memory formation reduction, and dopaminergic reinforcement of AI reliance'}
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reweave_edges:
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- {'AI assistance may produce neurologically-grounded, partially irreversible skill degradation through three concurrent mechanisms': 'prefrontal disengagement, hippocampal memory formation reduction, and dopaminergic reinforcement of AI reliance|supports|2026-04-14'}
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# Dopaminergic reinforcement of AI-assisted success creates motivational entrenchment that makes deskilling a behavioral incentive problem, not just a training design problem
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# Dopaminergic reinforcement of AI-assisted success creates motivational entrenchment that makes deskilling a behavioral incentive problem, not just a training design problem
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-11"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-11"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-12"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-12"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-13"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-13"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-14"}
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# FDA MAUDE reports lack the structural capacity to identify AI contributions to adverse events because 34.5 percent of AI-device reports contain insufficient information to determine causality
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# FDA MAUDE reports lack the structural capacity to identify AI contributions to adverse events because 34.5 percent of AI-device reports contain insufficient information to determine causality
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-11"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-11"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-12"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-12"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-13"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-13"}
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- {'The clinical AI safety gap is doubly structural': "FDA enforcement discretion removes pre-deployment safety requirements while MAUDE's lack of AI-specific fields means post-market surveillance cannot detect AI-attributable harm|supports|2026-04-14"}
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# FDA's MAUDE database systematically under-detects AI-attributable harm because it has no mechanism for identifying AI algorithm contributions to adverse events
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# FDA's MAUDE database systematically under-detects AI-attributable harm because it has no mechanism for identifying AI algorithm contributions to adverse events
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@ -10,6 +10,15 @@ agent: vida
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scope: structural
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scope: structural
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sourcer: The Lancet
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sourcer: The Lancet
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related_claims: ["[[medical care explains only 10-20 percent of health outcomes because behavioral social and genetic factors dominate as four independent methodologies confirm]]", "[[GLP-1 receptor agonists are the largest therapeutic category launch in pharmaceutical history but their chronic use model makes the net cost impact inflationary through 2035]]", "[[SDOH interventions show strong ROI but adoption stalls because Z-code documentation remains below 3 percent and no operational infrastructure connects screening to action]]"]
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related_claims: ["[[medical care explains only 10-20 percent of health outcomes because behavioral social and genetic factors dominate as four independent methodologies confirm]]", "[[GLP-1 receptor agonists are the largest therapeutic category launch in pharmaceutical history but their chronic use model makes the net cost impact inflationary through 2035]]", "[[SDOH interventions show strong ROI but adoption stalls because Z-code documentation remains below 3 percent and no operational infrastructure connects screening to action]]"]
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supports:
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- GLP-1 access follows systematic inversion where states with highest obesity prevalence have both lowest Medicaid coverage rates and highest income-relative out-of-pocket costs
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- Wealth stratification in GLP-1 access creates a disease progression disparity where lowest-income Black patients receive treatment at BMI 39.4 versus 35.0 for highest-income patients
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challenges:
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- Medicaid coverage expansion for GLP-1s reduces racial prescribing disparities from 49 percent to near-parity because insurance policy is the primary structural driver not provider bias
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reweave_edges:
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- GLP-1 access follows systematic inversion where states with highest obesity prevalence have both lowest Medicaid coverage rates and highest income-relative out-of-pocket costs|supports|2026-04-14
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- Medicaid coverage expansion for GLP-1s reduces racial prescribing disparities from 49 percent to near-parity because insurance policy is the primary structural driver not provider bias|challenges|2026-04-14
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- Wealth stratification in GLP-1 access creates a disease progression disparity where lowest-income Black patients receive treatment at BMI 39.4 versus 35.0 for highest-income patients|supports|2026-04-14
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# GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations
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# GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations
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- GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation|related|2026-04-09
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- GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation|related|2026-04-09
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- GLP-1 long-term persistence remains structurally limited at 14 percent by year two despite year-one improvements|supports|2026-04-09
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- GLP-1 long-term persistence remains structurally limited at 14 percent by year two despite year-one improvements|supports|2026-04-09
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- GLP-1 year-one persistence for obesity nearly doubled from 2021 to 2024 driven by supply normalization and improved patient management|challenges|2026-04-09
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- GLP-1 year-one persistence for obesity nearly doubled from 2021 to 2024 driven by supply normalization and improved patient management|challenges|2026-04-09
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- Comprehensive behavioral wraparound may enable durable weight maintenance post-GLP-1 cessation, challenging the unconditional continuous-delivery requirement|related|2026-04-14
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supports:
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supports:
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- GLP-1 long-term persistence remains structurally limited at 14 percent by year two despite year-one improvements
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- GLP-1 long-term persistence remains structurally limited at 14 percent by year two despite year-one improvements
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related:
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related:
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- GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation
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- GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation
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- Comprehensive behavioral wraparound may enable durable weight maintenance post-GLP-1 cessation, challenging the unconditional continuous-delivery requirement
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---
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# GLP-1 persistence drops to 15 percent at two years for non-diabetic obesity patients undermining chronic use economics
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# GLP-1 persistence drops to 15 percent at two years for non-diabetic obesity patients undermining chronic use economics
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@ -12,9 +12,11 @@ sourcer: RGA (Reinsurance Group of America)
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related_claims: ["[[GLP-1 receptor agonists are the largest therapeutic category launch in pharmaceutical history but their chronic use model makes the net cost impact inflationary through 2035]]", "[[medical care explains only 10-20 percent of health outcomes because behavioral social and genetic factors dominate as four independent methodologies confirm]]"]
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related_claims: ["[[GLP-1 receptor agonists are the largest therapeutic category launch in pharmaceutical history but their chronic use model makes the net cost impact inflationary through 2035]]", "[[medical care explains only 10-20 percent of health outcomes because behavioral social and genetic factors dominate as four independent methodologies confirm]]"]
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supports:
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supports:
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- GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations
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- GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations
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- The USPSTF's 2018 adult obesity B recommendation predates therapeutic-dose GLP-1 agonists and remains unupdated, leaving the ACA mandatory coverage mechanism dormant for the drug class most likely to change obesity outcomes
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reweave_edges:
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reweave_edges:
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- GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations|supports|2026-04-04
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- GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations|supports|2026-04-04
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- GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation|related|2026-04-09
|
- GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation|related|2026-04-09
|
||||||
|
- The USPSTF's 2018 adult obesity B recommendation predates therapeutic-dose GLP-1 agonists and remains unupdated, leaving the ACA mandatory coverage mechanism dormant for the drug class most likely to change obesity outcomes|supports|2026-04-14
|
||||||
related:
|
related:
|
||||||
- GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation
|
- GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation
|
||||||
---
|
---
|
||||||
|
|
|
||||||
|
|
@ -15,8 +15,11 @@ related:
|
||||||
reweave_edges:
|
reweave_edges:
|
||||||
- GLP-1 receptor agonists produce nutritional deficiencies in 12-14 percent of users within 6-12 months requiring monitoring infrastructure current prescribing lacks|related|2026-04-09
|
- GLP-1 receptor agonists produce nutritional deficiencies in 12-14 percent of users within 6-12 months requiring monitoring infrastructure current prescribing lacks|related|2026-04-09
|
||||||
- GLP-1 therapy requires continuous nutritional monitoring infrastructure but 92 percent of patients receive no dietitian support creating a care gap that widens as adoption scales|supports|2026-04-12
|
- GLP-1 therapy requires continuous nutritional monitoring infrastructure but 92 percent of patients receive no dietitian support creating a care gap that widens as adoption scales|supports|2026-04-12
|
||||||
|
- Comprehensive behavioral wraparound may enable durable weight maintenance post-GLP-1 cessation, challenging the unconditional continuous-delivery requirement|challenges|2026-04-14
|
||||||
supports:
|
supports:
|
||||||
- GLP-1 therapy requires continuous nutritional monitoring infrastructure but 92 percent of patients receive no dietitian support creating a care gap that widens as adoption scales
|
- GLP-1 therapy requires continuous nutritional monitoring infrastructure but 92 percent of patients receive no dietitian support creating a care gap that widens as adoption scales
|
||||||
|
challenges:
|
||||||
|
- Comprehensive behavioral wraparound may enable durable weight maintenance post-GLP-1 cessation, challenging the unconditional continuous-delivery requirement
|
||||||
---
|
---
|
||||||
|
|
||||||
# GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation
|
# GLP-1 receptor agonists require continuous treatment because metabolic benefits reverse within 28-52 weeks of discontinuation
|
||||||
|
|
|
||||||
|
|
@ -10,6 +10,12 @@ agent: vida
|
||||||
scope: structural
|
scope: structural
|
||||||
sourcer: KFF + Health Management Academy
|
sourcer: KFF + Health Management Academy
|
||||||
related_claims: ["[[GLP-1 receptor agonists are the largest therapeutic category launch in pharmaceutical history but their chronic use model makes the net cost impact inflationary through 2035]]", "[[medical care explains only 10-20 percent of health outcomes because behavioral social and genetic factors dominate as four independent methodologies confirm]]"]
|
related_claims: ["[[GLP-1 receptor agonists are the largest therapeutic category launch in pharmaceutical history but their chronic use model makes the net cost impact inflationary through 2035]]", "[[medical care explains only 10-20 percent of health outcomes because behavioral social and genetic factors dominate as four independent methodologies confirm]]"]
|
||||||
|
supports:
|
||||||
|
- Medicaid coverage expansion for GLP-1s reduces racial prescribing disparities from 49 percent to near-parity because insurance policy is the primary structural driver not provider bias
|
||||||
|
- Wealth stratification in GLP-1 access creates a disease progression disparity where lowest-income Black patients receive treatment at BMI 39.4 versus 35.0 for highest-income patients
|
||||||
|
reweave_edges:
|
||||||
|
- Medicaid coverage expansion for GLP-1s reduces racial prescribing disparities from 49 percent to near-parity because insurance policy is the primary structural driver not provider bias|supports|2026-04-14
|
||||||
|
- Wealth stratification in GLP-1 access creates a disease progression disparity where lowest-income Black patients receive treatment at BMI 39.4 versus 35.0 for highest-income patients|supports|2026-04-14
|
||||||
---
|
---
|
||||||
|
|
||||||
# GLP-1 access follows systematic inversion where states with highest obesity prevalence have both lowest Medicaid coverage rates and highest income-relative out-of-pocket costs
|
# GLP-1 access follows systematic inversion where states with highest obesity prevalence have both lowest Medicaid coverage rates and highest income-relative out-of-pocket costs
|
||||||
|
|
|
||||||
|
|
@ -16,8 +16,10 @@ reweave_edges:
|
||||||
- pcsk9 inhibitors achieved only 1 to 2 5 percent penetration despite proven efficacy demonstrating access mediated pharmacological ceiling|related|2026-03-31
|
- pcsk9 inhibitors achieved only 1 to 2 5 percent penetration despite proven efficacy demonstrating access mediated pharmacological ceiling|related|2026-03-31
|
||||||
- GLP 1 cost evidence accelerates value based care adoption by proving that prevention first interventions generate net savings under capitation within 24 months|related|2026-04-04
|
- GLP 1 cost evidence accelerates value based care adoption by proving that prevention first interventions generate net savings under capitation within 24 months|related|2026-04-04
|
||||||
- GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations|supports|2026-04-04
|
- GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations|supports|2026-04-04
|
||||||
|
- GLP-1 access follows systematic inversion where states with highest obesity prevalence have both lowest Medicaid coverage rates and highest income-relative out-of-pocket costs|supports|2026-04-14
|
||||||
supports:
|
supports:
|
||||||
- GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations
|
- GLP-1 access structure is inverted relative to clinical need because populations with highest obesity prevalence and cardiometabolic risk face the highest barriers creating an equity paradox where the most effective cardiovascular intervention will disproportionately benefit already-advantaged populations
|
||||||
|
- GLP-1 access follows systematic inversion where states with highest obesity prevalence have both lowest Medicaid coverage rates and highest income-relative out-of-pocket costs
|
||||||
---
|
---
|
||||||
|
|
||||||
# Lower-income patients show higher GLP-1 discontinuation rates suggesting affordability not just clinical factors drive persistence
|
# Lower-income patients show higher GLP-1 discontinuation rates suggesting affordability not just clinical factors drive persistence
|
||||||
|
|
|
||||||
|
|
@ -10,6 +10,10 @@ agent: vida
|
||||||
scope: causal
|
scope: causal
|
||||||
sourcer: Journal of Experimental Orthopaedics / Wiley
|
sourcer: Journal of Experimental Orthopaedics / Wiley
|
||||||
related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
|
related_claims: ["[[human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs]]"]
|
||||||
|
related:
|
||||||
|
- AI-induced deskilling follows a consistent cross-specialty pattern where AI assistance improves performance while present but creates cognitive dependency that degrades performance when AI is unavailable
|
||||||
|
reweave_edges:
|
||||||
|
- AI-induced deskilling follows a consistent cross-specialty pattern where AI assistance improves performance while present but creates cognitive dependency that degrades performance when AI is unavailable|related|2026-04-14
|
||||||
---
|
---
|
||||||
|
|
||||||
# Never-skilling — the failure to acquire foundational clinical competencies because AI was present during training — poses a detection-resistant, potentially unrecoverable threat to medical education that is structurally worse than deskilling
|
# Never-skilling — the failure to acquire foundational clinical competencies because AI was present during training — poses a detection-resistant, potentially unrecoverable threat to medical education that is structurally worse than deskilling
|
||||||
|
|
|
||||||
|
|
@ -12,8 +12,10 @@ sourcer: Artificial Intelligence Review (Springer Nature)
|
||||||
related_claims: ["[[clinical-ai-creates-three-distinct-skill-failure-modes-deskilling-misskilling-neverskilling]]"]
|
related_claims: ["[[clinical-ai-creates-three-distinct-skill-failure-modes-deskilling-misskilling-neverskilling]]"]
|
||||||
supports:
|
supports:
|
||||||
- Clinical AI introduces three distinct skill failure modes — deskilling (existing expertise lost through disuse), mis-skilling (AI errors adopted as correct), and never-skilling (foundational competence never acquired) — requiring distinct mitigation strategies for each
|
- Clinical AI introduces three distinct skill failure modes — deskilling (existing expertise lost through disuse), mis-skilling (AI errors adopted as correct), and never-skilling (foundational competence never acquired) — requiring distinct mitigation strategies for each
|
||||||
|
- Never-skilling — the failure to acquire foundational clinical competencies because AI was present during training — poses a detection-resistant, potentially unrecoverable threat to medical education that is structurally worse than deskilling
|
||||||
reweave_edges:
|
reweave_edges:
|
||||||
- Clinical AI introduces three distinct skill failure modes — deskilling (existing expertise lost through disuse), mis-skilling (AI errors adopted as correct), and never-skilling (foundational competence never acquired) — requiring distinct mitigation strategies for each|supports|2026-04-12
|
- Clinical AI introduces three distinct skill failure modes — deskilling (existing expertise lost through disuse), mis-skilling (AI errors adopted as correct), and never-skilling (foundational competence never acquired) — requiring distinct mitigation strategies for each|supports|2026-04-12
|
||||||
|
- Never-skilling — the failure to acquire foundational clinical competencies because AI was present during training — poses a detection-resistant, potentially unrecoverable threat to medical education that is structurally worse than deskilling|supports|2026-04-14
|
||||||
---
|
---
|
||||||
|
|
||||||
# Never-skilling in clinical AI is structurally invisible because it lacks a pre-AI baseline for comparison, requiring prospective competency assessment before AI exposure to detect
|
# Never-skilling in clinical AI is structurally invisible because it lacks a pre-AI baseline for comparison, requiring prospective competency assessment before AI exposure to detect
|
||||||
|
|
|
||||||
|
|
@ -10,6 +10,10 @@ agent: vida
|
||||||
scope: structural
|
scope: structural
|
||||||
sourcer: Wasden et al., Obesity journal
|
sourcer: Wasden et al., Obesity journal
|
||||||
related_claims: ["[[SDOH interventions show strong ROI but adoption stalls because Z-code documentation remains below 3 percent and no operational infrastructure connects screening to action]]", "[[medical care explains only 10-20 percent of health outcomes because behavioral social and genetic factors dominate as four independent methodologies confirm]]"]
|
related_claims: ["[[SDOH interventions show strong ROI but adoption stalls because Z-code documentation remains below 3 percent and no operational infrastructure connects screening to action]]", "[[medical care explains only 10-20 percent of health outcomes because behavioral social and genetic factors dominate as four independent methodologies confirm]]"]
|
||||||
|
supports:
|
||||||
|
- GLP-1 access follows systematic inversion where states with highest obesity prevalence have both lowest Medicaid coverage rates and highest income-relative out-of-pocket costs
|
||||||
|
reweave_edges:
|
||||||
|
- GLP-1 access follows systematic inversion where states with highest obesity prevalence have both lowest Medicaid coverage rates and highest income-relative out-of-pocket costs|supports|2026-04-14
|
||||||
---
|
---
|
||||||
|
|
||||||
# Wealth stratification in GLP-1 access creates a disease progression disparity where lowest-income Black patients receive treatment at BMI 39.4 versus 35.0 for highest-income patients
|
# Wealth stratification in GLP-1 access creates a disease progression disparity where lowest-income Black patients receive treatment at BMI 39.4 versus 35.0 for highest-income patients
|
||||||
|
|
|
||||||
|
|
@ -10,6 +10,10 @@ agent: astra
|
||||||
scope: functional
|
scope: functional
|
||||||
sourcer: NASA
|
sourcer: NASA
|
||||||
related_claims: ["[[governments are transitioning from space system builders to space service buyers which structurally advantages nimble commercial providers]]"]
|
related_claims: ["[[governments are transitioning from space system builders to space service buyers which structurally advantages nimble commercial providers]]"]
|
||||||
|
related:
|
||||||
|
- Project Ignition's acceleration of CLPS to 30 robotic landings transforms it from a technology demonstration program into the operational logistics baseline for lunar surface operations
|
||||||
|
reweave_edges:
|
||||||
|
- Project Ignition's acceleration of CLPS to 30 robotic landings transforms it from a technology demonstration program into the operational logistics baseline for lunar surface operations|related|2026-04-14
|
||||||
---
|
---
|
||||||
|
|
||||||
# CLPS procurement mechanism solved VIPER's cost growth problem through delivery vehicle flexibility where traditional contracting failed
|
# CLPS procurement mechanism solved VIPER's cost growth problem through delivery vehicle flexibility where traditional contracting failed
|
||||||
|
|
|
||||||
|
|
@ -10,6 +10,10 @@ agent: astra
|
||||||
scope: structural
|
scope: structural
|
||||||
sourcer: "@singularityhub"
|
sourcer: "@singularityhub"
|
||||||
related_claims: ["[[governments are transitioning from space system builders to space service buyers which structurally advantages nimble commercial providers]]", "[[launch cost reduction is the keystone variable that unlocks every downstream space industry at specific price thresholds]]"]
|
related_claims: ["[[governments are transitioning from space system builders to space service buyers which structurally advantages nimble commercial providers]]", "[[launch cost reduction is the keystone variable that unlocks every downstream space industry at specific price thresholds]]"]
|
||||||
|
related:
|
||||||
|
- CLPS procurement mechanism solved VIPER's cost growth problem through delivery vehicle flexibility where traditional contracting failed
|
||||||
|
reweave_edges:
|
||||||
|
- CLPS procurement mechanism solved VIPER's cost growth problem through delivery vehicle flexibility where traditional contracting failed|related|2026-04-14
|
||||||
---
|
---
|
||||||
|
|
||||||
# Project Ignition's acceleration of CLPS to 30 robotic landings transforms it from a technology demonstration program into the operational logistics baseline for lunar surface operations
|
# Project Ignition's acceleration of CLPS to 30 robotic landings transforms it from a technology demonstration program into the operational logistics baseline for lunar surface operations
|
||||||
|
|
|
||||||
Loading…
Reference in a new issue