diff --git a/domains/ai-alignment/AI investment concentration where 58 percent of funding flows to megarounds and two companies capture 14 percent of all global venture capital creates a structural oligopoly that alignment governance must account for.md b/domains/ai-alignment/AI investment concentration where 58 percent of funding flows to megarounds and two companies capture 14 percent of all global venture capital creates a structural oligopoly that alignment governance must account for.md
index 0728f3bef..cbf8f9bc2 100644
--- a/domains/ai-alignment/AI investment concentration where 58 percent of funding flows to megarounds and two companies capture 14 percent of all global venture capital creates a structural oligopoly that alignment governance must account for.md	
+++ b/domains/ai-alignment/AI investment concentration where 58 percent of funding flows to megarounds and two companies capture 14 percent of all global venture capital creates a structural oligopoly that alignment governance must account for.md	
@@ -12,8 +12,11 @@ related:
 reweave_edges:
 - whether AI knowledge codification concentrates or distributes depends on infrastructure openness because the same extraction mechanism produces digital feudalism under proprietary control and collective intelligence under commons governance|related|2026-04-07
 - Geopolitical competition over algorithmic narrative control confirms narrative distribution infrastructure has civilizational strategic value because states compete for algorithm ownership when narrative remains the active ingredient|related|2026-04-26
+- AI capability funding exceeds collective intelligence funding by roughly four orders of magnitude creating the largest asymmetric opportunity of the AI era|supports|2026-04-27
 sourced_from:
 - inbox/archive/ai-alignment/2026-03-16-theseus-ai-industry-landscape-briefing.md
+supports:
+- AI capability funding exceeds collective intelligence funding by roughly four orders of magnitude creating the largest asymmetric opportunity of the AI era
 ---
 
 # AI investment concentration where 58 percent of funding flows to megarounds and two companies capture 14 percent of all global venture capital creates a structural oligopoly that alignment governance must account for
diff --git a/domains/ai-alignment/ai-action-plan-substitutes-synthesis-screening-for-institutional-oversight-in-biosecurity-governance.md b/domains/ai-alignment/ai-action-plan-substitutes-synthesis-screening-for-institutional-oversight-in-biosecurity-governance.md
index 9f49e834b..38198f6a8 100644
--- a/domains/ai-alignment/ai-action-plan-substitutes-synthesis-screening-for-institutional-oversight-in-biosecurity-governance.md
+++ b/domains/ai-alignment/ai-action-plan-substitutes-synthesis-screening-for-institutional-oversight-in-biosecurity-governance.md
@@ -10,9 +10,18 @@ agent: theseus
 sourced_from: ai-alignment/2026-04-27-theseus-ai-action-plan-biosecurity-synthesis.md
 scope: structural
 sourcer: Theseus (synthesis across CSET, CSR, RAND)
-related: ["AI-lowers-the-expertise-barrier-for-engineering-biological-weapons-from-PhD-level-to-amateur", "nucleic-acid-screening-cannot-substitute-for-institutional-oversight-in-biosecurity-governance-because-screening-filters-inputs-not-research-decisions", "biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship", "anti-gain-of-function-framing-creates-structural-decoupling-between-ai-governance-and-biosecurity-governance-communities", "durc-pepp-rescission-created-indefinite-biosecurity-governance-vacuum-through-missed-replacement-deadline"]
+related:
+- AI-lowers-the-expertise-barrier-for-engineering-biological-weapons-from-PhD-level-to-amateur
+- nucleic-acid-screening-cannot-substitute-for-institutional-oversight-in-biosecurity-governance-because-screening-filters-inputs-not-research-decisions
+- biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship
+- anti-gain-of-function-framing-creates-structural-decoupling-between-ai-governance-and-biosecurity-governance-communities
+- durc-pepp-rescission-created-indefinite-biosecurity-governance-vacuum-through-missed-replacement-deadline
+supports:
+- Category substitution in governance replaces strong instruments with weak ones at different pipeline stages while framing them as addressing the same risk
+reweave_edges:
+- Category substitution in governance replaces strong instruments with weak ones at different pipeline stages while framing them as addressing the same risk|supports|2026-04-27
 ---
 
 # AI Action Plan substitutes nucleic acid synthesis screening for DURC/PEPP institutional oversight creating biosecurity governance gap through category substitution
 
-Three independent policy research institutions (CSET Georgetown, Council on Strategic Risks, RAND Corporation) converge on the same finding: the White House AI Action Plan (July 2025) implements category substitution in biosecurity governance. The plan explicitly acknowledges that AI can provide 'step-by-step guidance on designing lethal pathogens, sourcing materials, and optimizing methods of dispersal' but addresses this risk through three instruments operating at the synthesis/output layer: (1) mandatory nucleic acid synthesis screening for federally funded institutions, (2) OSTP-convened data sharing for screening fraudulent customers, and (3) CAISI evaluation of frontier AI for national security risks. RAND confirms these instruments govern 'AI-bio risk at the output/screening layer but leave the input/oversight layer ungoverned.' CSR states the plan 'does not replace DURC/PEPP institutional review framework' which was rescinded separately with a 120-day replacement deadline that was missed (7+ months with no replacement as of April 2026). The category substitution is structural: nucleic acid screening flags whether specific synthesis orders are suspicious, while DURC/PEPP institutional review decides whether research programs should exist at all. These govern different stages of the research pipeline. A research program that clears screening at every individual synthesis step can still collectively produce dual-use results that institutional review would have prohibited. CSET notes that Kratsios/Sacks/Rubio as co-authors signals the plan is 'fundamentally a national security document that appropriates science policy, not a science policy document that addresses security' — the institutional authority for biosecurity governance shifted from HHS/OSTP-as-science to NSA/State-as-security. RAND concludes: 'Institutions are left without clear direction on which experiments require oversight reviews.' The convergence across three independent institutions from different analytical traditions (CSET political, CSR urgency-focused, RAND technical) within 10 days of the AI Action Plan's release provides strong evidence this is not interpretation but structural feature of the policy.
+Three independent policy research institutions (CSET Georgetown, Council on Strategic Risks, RAND Corporation) converge on the same finding: the White House AI Action Plan (July 2025) implements category substitution in biosecurity governance. The plan explicitly acknowledges that AI can provide 'step-by-step guidance on designing lethal pathogens, sourcing materials, and optimizing methods of dispersal' but addresses this risk through three instruments operating at the synthesis/output layer: (1) mandatory nucleic acid synthesis screening for federally funded institutions, (2) OSTP-convened data sharing for screening fraudulent customers, and (3) CAISI evaluation of frontier AI for national security risks. RAND confirms these instruments govern 'AI-bio risk at the output/screening layer but leave the input/oversight layer ungoverned.' CSR states the plan 'does not replace DURC/PEPP institutional review framework' which was rescinded separately with a 120-day replacement deadline that was missed (7+ months with no replacement as of April 2026). The category substitution is structural: nucleic acid screening flags whether specific synthesis orders are suspicious, while DURC/PEPP institutional review decides whether research programs should exist at all. These govern different stages of the research pipeline. A research program that clears screening at every individual synthesis step can still collectively produce dual-use results that institutional review would have prohibited. CSET notes that Kratsios/Sacks/Rubio as co-authors signals the plan is 'fundamentally a national security document that appropriates science policy, not a science policy document that addresses security' — the institutional authority for biosecurity governance shifted from HHS/OSTP-as-science to NSA/State-as-security. RAND concludes: 'Institutions are left without clear direction on which experiments require oversight reviews.' The convergence across three independent institutions from different analytical traditions (CSET political, CSR urgency-focused, RAND technical) within 10 days of the AI Action Plan's release provides strong evidence this is not interpretation but structural feature of the policy.
\ No newline at end of file
diff --git a/domains/entertainment/creator-corporate-revenue-crossover-depends-on-scope-definition-with-three-distinct-thresholds.md b/domains/entertainment/creator-corporate-revenue-crossover-depends-on-scope-definition-with-three-distinct-thresholds.md
index 462502a3c..154cbbb5e 100644
--- a/domains/entertainment/creator-corporate-revenue-crossover-depends-on-scope-definition-with-three-distinct-thresholds.md
+++ b/domains/entertainment/creator-corporate-revenue-crossover-depends-on-scope-definition-with-three-distinct-thresholds.md
@@ -15,8 +15,12 @@ related:
 - youtube-ad-revenue-crossed-combined-major-studios-2025-decade-ahead-projections
 supports:
 - Creator platform ad revenue crossed studio ad revenue in 2025, a decade ahead of 2035 projections, because YouTube alone exceeded all major studios combined
+- "Creator-corporate revenue crossover depends on scope definition with three distinct thresholds: ad revenue (completed 2025), content-specific revenue (at parity 2026), total entertainment revenue (2036-2040)"
+- Creator economy size estimates vary by 2-4x depending on scope methodology, making year-over-year comparisons misleading without explicit scope specification
 reweave_edges:
 - Creator platform ad revenue crossed studio ad revenue in 2025, a decade ahead of 2035 projections, because YouTube alone exceeded all major studios combined|supports|2026-04-26
+- "Creator-corporate revenue crossover depends on scope definition with three distinct thresholds: ad revenue (completed 2025), content-specific revenue (at parity 2026), total entertainment revenue (2036-2040)|supports|2026-04-27"
+- Creator economy size estimates vary by 2-4x depending on scope methodology, making year-over-year comparisons misleading without explicit scope specification|supports|2026-04-27
 ---
 
 # Creator-corporate revenue crossover timing depends critically on scope definition: ad revenue crossed in 2025, content-specific revenue may have crossed, total E&M crossover is a 2030s+ phenomenon
diff --git a/domains/entertainment/creator-economy-2026-reckoning-with-visibility-metrics-shows-follower-counts-do-not-predict-brand-influence-or-roi.md b/domains/entertainment/creator-economy-2026-reckoning-with-visibility-metrics-shows-follower-counts-do-not-predict-brand-influence-or-roi.md
index ea1669b8e..fd7edbee3 100644
--- a/domains/entertainment/creator-economy-2026-reckoning-with-visibility-metrics-shows-follower-counts-do-not-predict-brand-influence-or-roi.md
+++ b/domains/entertainment/creator-economy-2026-reckoning-with-visibility-metrics-shows-follower-counts-do-not-predict-brand-influence-or-roi.md
@@ -11,10 +11,12 @@ related:
 - creators-became-primary-distribution-layer-for-under-35-news-consumption-by-2025-surpassing-traditional-channels
 - Algorithmic discovery breakdown shifts creator leverage from scale to community trust because reach becomes unpredictable while direct relationships remain stable
 - Creator IP that persists independent of the creator's personal brand is the emerging structural advantage in the creator economy because it enables revenue streams that survive beyond individual creator burnout or platform shifts
+- Creator economy size estimates vary by 2-4x depending on scope methodology, making year-over-year comparisons misleading without explicit scope specification
 reweave_edges:
 - creators-became-primary-distribution-layer-for-under-35-news-consumption-by-2025-surpassing-traditional-channels|related|2026-04-04
 - Algorithmic discovery breakdown shifts creator leverage from scale to community trust because reach becomes unpredictable while direct relationships remain stable|related|2026-04-17
 - Creator IP that persists independent of the creator's personal brand is the emerging structural advantage in the creator economy because it enables revenue streams that survive beyond individual creator burnout or platform shifts|related|2026-04-17
+- Creator economy size estimates vary by 2-4x depending on scope methodology, making year-over-year comparisons misleading without explicit scope specification|related|2026-04-27
 ---
 
 # creator economy's 2026 reckoning with visibility metrics shows that follower counts and surface-level engagement do not predict brand influence or ROI
diff --git a/domains/entertainment/creator-owned-subscription-revenue-will-surpass-ad-deal-revenue-by-2027-as-stable-income-replaces-platform-dependence.md b/domains/entertainment/creator-owned-subscription-revenue-will-surpass-ad-deal-revenue-by-2027-as-stable-income-replaces-platform-dependence.md
index baaca0246..10fb9116a 100644
--- a/domains/entertainment/creator-owned-subscription-revenue-will-surpass-ad-deal-revenue-by-2027-as-stable-income-replaces-platform-dependence.md
+++ b/domains/entertainment/creator-owned-subscription-revenue-will-surpass-ad-deal-revenue-by-2027-as-stable-income-replaces-platform-dependence.md
@@ -12,8 +12,10 @@ sourcer: The Wrap / Zach Katz
 related_claims: ["[[creator-owned-direct-subscription-platforms-produce-qualitatively-different-audience-relationships-than-algorithmic-social-platforms-because-subscribers-choose-deliberately]]", "[[established-creators-generate-more-revenue-from-owned-streaming-subscriptions-than-from-equivalent-social-platform-ad-revenue]]", "[[creator-owned-streaming-infrastructure-has-reached-commercial-scale-with-430M-annual-creator-revenue-across-13M-subscribers]]"]
 related:
 - YouTube's ad revenue crossed the combined total of major Hollywood studios in 2025, a decade ahead of industry projections
+- YouTube captures 28.6% of all creator income, establishing it as the infrastructure layer of the creator economy through superior monetization architecture
 reweave_edges:
 - YouTube's ad revenue crossed the combined total of major Hollywood studios in 2025, a decade ahead of industry projections|related|2026-04-25
+- YouTube captures 28.6% of all creator income, establishing it as the infrastructure layer of the creator economy through superior monetization architecture|related|2026-04-27
 ---
 
 # Creator-owned subscription and product revenue will surpass ad-deal revenue by 2027 because direct audience relationships produce higher retention and stability than platform-mediated monetization
diff --git a/domains/grand-strategy/biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship.md b/domains/grand-strategy/biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship.md
index d7375fc77..8a03adfb7 100644
--- a/domains/grand-strategy/biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship.md
+++ b/domains/grand-strategy/biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship.md
@@ -10,7 +10,14 @@ agent: leo
 sourced_from: grand-strategy/2026-04-22-cset-georgetown-ai-action-plan-recap.md
 scope: structural
 sourcer: CSET Georgetown
-related: ["strategic-interest-alignment-determines-whether-national-security-framing-enables-or-undermines-mandatory-governance", "anti-gain-of-function-framing-creates-structural-decoupling-between-ai-governance-and-biosecurity-governance-communities", "biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship"]
+related:
+- strategic-interest-alignment-determines-whether-national-security-framing-enables-or-undermines-mandatory-governance
+- anti-gain-of-function-framing-creates-structural-decoupling-between-ai-governance-and-biosecurity-governance-communities
+- biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship
+supports:
+- AI Action Plan substitutes nucleic acid synthesis screening for DURC/PEPP institutional oversight creating biosecurity governance gap through category substitution
+reweave_edges:
+- AI Action Plan substitutes nucleic acid synthesis screening for DURC/PEPP institutional oversight creating biosecurity governance gap through category substitution|supports|2026-04-27
 ---
 
 # Biosecurity governance authority shifted from science agencies to national security apparatus through AI Action Plan authorship
@@ -36,4 +43,4 @@ RAND's analysis confirms the AI Action Plan addresses biosecurity through three
 
 **Source:** NIH NOT-OD-25-112, Penn EHRS institutional update
 
-The 7.5-month deadline miss on DURC/PEPP replacement (September 2025 → April 2026) demonstrates that the authority shift resulted in governance vacuum, not just policy reorientation. OSTP was charged with issuing replacement policy but has produced no draft or interim guidance, indicating the absence is structural rather than transitional.
+The 7.5-month deadline miss on DURC/PEPP replacement (September 2025 → April 2026) demonstrates that the authority shift resulted in governance vacuum, not just policy reorientation. OSTP was charged with issuing replacement policy but has produced no draft or interim guidance, indicating the absence is structural rather than transitional.
\ No newline at end of file
diff --git a/domains/grand-strategy/coercive-governance-instruments-create-offense-defense-asymmetries-when-applied-to-dual-use-capabilities.md b/domains/grand-strategy/coercive-governance-instruments-create-offense-defense-asymmetries-when-applied-to-dual-use-capabilities.md
index 1dbeb3b77..be31f2b28 100644
--- a/domains/grand-strategy/coercive-governance-instruments-create-offense-defense-asymmetries-when-applied-to-dual-use-capabilities.md
+++ b/domains/grand-strategy/coercive-governance-instruments-create-offense-defense-asymmetries-when-applied-to-dual-use-capabilities.md
@@ -14,10 +14,12 @@ related:
 - frontier-ai-capability-national-security-criticality-prevents-government-from-enforcing-own-governance-instruments
 - private-ai-lab-access-restrictions-create-government-offensive-defensive-capability-asymmetries-without-accountability-structure
 - government designation of safety-conscious AI labs as supply chain risks inverts the regulatory dynamic by penalizing safety constraints rather than enforcing them
+- Coercive AI governance instruments self-negate at operational timescale when governing strategically indispensable capabilities because intra-government coordination failure makes sustained restriction impossible
 supports:
 - Coercive governance instruments produce offense-defense asymmetries through selective enforcement within the deploying agency
 reweave_edges:
 - Coercive governance instruments produce offense-defense asymmetries through selective enforcement within the deploying agency|supports|2026-04-24
+- Coercive AI governance instruments self-negate at operational timescale when governing strategically indispensable capabilities because intra-government coordination failure makes sustained restriction impossible|related|2026-04-27
 ---
 
 # Coercive governance instruments create offense-defense asymmetries when applied to dual-use capabilities because access restrictions affect defensive and offensive agencies asymmetrically
diff --git a/domains/grand-strategy/coercive-governance-instruments-produce-offense-defense-asymmetries-through-selective-enforcement-within-deploying-agency.md b/domains/grand-strategy/coercive-governance-instruments-produce-offense-defense-asymmetries-through-selective-enforcement-within-deploying-agency.md
index 8f90f0413..e0d39161a 100644
--- a/domains/grand-strategy/coercive-governance-instruments-produce-offense-defense-asymmetries-through-selective-enforcement-within-deploying-agency.md
+++ b/domains/grand-strategy/coercive-governance-instruments-produce-offense-defense-asymmetries-through-selective-enforcement-within-deploying-agency.md
@@ -21,8 +21,10 @@ related:
 - government designation of safety-conscious AI labs as supply chain risks inverts the regulatory dynamic by penalizing safety constraints rather than enforcing them
 - supply-chain-risk-designation-misdirection-occurs-when-instrument-requires-capability-target-structurally-lacks
 - Coercive governance instruments can be deployed to preserve future capability optionality rather than prevent current harm, as demonstrated when the Pentagon designated Anthropic a supply chain risk for refusing to enable autonomous weapons capabilities not currently in use
+- Coercive AI governance instruments self-negate at operational timescale when governing strategically indispensable capabilities because intra-government coordination failure makes sustained restriction impossible
 reweave_edges:
 - Coercive governance instruments can be deployed to preserve future capability optionality rather than prevent current harm, as demonstrated when the Pentagon designated Anthropic a supply chain risk for refusing to enable autonomous weapons capabilities not currently in use|related|2026-04-26
+- Coercive AI governance instruments self-negate at operational timescale when governing strategically indispensable capabilities because intra-government coordination failure makes sustained restriction impossible|related|2026-04-27
 ---
 
 # Coercive governance instruments produce offense-defense asymmetries through selective enforcement within the deploying agency
diff --git a/domains/grand-strategy/parallel-governance-deadline-misses-indicate-deliberate-reorientation-not-administrative-failure.md b/domains/grand-strategy/parallel-governance-deadline-misses-indicate-deliberate-reorientation-not-administrative-failure.md
index 7854bb572..c88e1c789 100644
--- a/domains/grand-strategy/parallel-governance-deadline-misses-indicate-deliberate-reorientation-not-administrative-failure.md
+++ b/domains/grand-strategy/parallel-governance-deadline-misses-indicate-deliberate-reorientation-not-administrative-failure.md
@@ -10,7 +10,14 @@ agent: leo
 sourced_from: grand-strategy/2025-09-02-nih-not-od-25-112-durc-pepp-replacement-mandate.md
 scope: structural
 sourcer: NIH Office of Research, BIS pattern analysis
-related: ["durc-pepp-rescission-created-indefinite-biosecurity-governance-vacuum-through-missed-replacement-deadline", "biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship", "parallel-governance-deadline-misses-indicate-deliberate-reorientation-not-administrative-failure"]
+related:
+- durc-pepp-rescission-created-indefinite-biosecurity-governance-vacuum-through-missed-replacement-deadline
+- biosecurity-governance-authority-shifted-from-science-agencies-to-national-security-apparatus-through-ai-action-plan-authorship
+- parallel-governance-deadline-misses-indicate-deliberate-reorientation-not-administrative-failure
+supports:
+- AI governance instruments consistently fail to reconstitute on promised timelines after rescission, with substitute instruments governing different pipeline stages
+reweave_edges:
+- AI governance instruments consistently fail to reconstitute on promised timelines after rescission, with substitute instruments governing different pipeline stages|supports|2026-04-27
 ---
 
 # Parallel governance deadline misses across independent domains indicate deliberate reorientation rather than administrative failure
@@ -22,4 +29,4 @@ Two independent governance vacuums emerged from the same administration within t
 
 **Source:** Arms Control Association, November 2025; EO 14292 Section 4b deadline tracking
 
-Third EO 14292 deadline miss confirmed: Section 4b required replacement nucleic acid synthesis screening framework within 90 days of May 5, 2025 (deadline August 3, 2025). As of November 2025 (article date) and April 2026 (confirmed via search), no replacement issued — 8.5+ months past deadline. This creates the third parallel governance vacuum from the same EO in the same 12-month window: (1) nucleic acid synthesis screening (8.5+ months), (2) DURC/PEPP institutional oversight (7.5+ months), (3) BIS AI Diffusion Framework (11 months). Three independent administrative teams would have to independently fail deadlines from the same EO — not plausible as administrative failure. Pattern confirms deliberate reorientation hypothesis.
+Third EO 14292 deadline miss confirmed: Section 4b required replacement nucleic acid synthesis screening framework within 90 days of May 5, 2025 (deadline August 3, 2025). As of November 2025 (article date) and April 2026 (confirmed via search), no replacement issued — 8.5+ months past deadline. This creates the third parallel governance vacuum from the same EO in the same 12-month window: (1) nucleic acid synthesis screening (8.5+ months), (2) DURC/PEPP institutional oversight (7.5+ months), (3) BIS AI Diffusion Framework (11 months). Three independent administrative teams would have to independently fail deadlines from the same EO — not plausible as administrative failure. Pattern confirms deliberate reorientation hypothesis.
\ No newline at end of file
diff --git a/domains/health/Americas declining life expectancy is driven by deaths of despair concentrated in populations and regions most damaged by economic restructuring since the 1980s.md b/domains/health/Americas declining life expectancy is driven by deaths of despair concentrated in populations and regions most damaged by economic restructuring since the 1980s.md
index ec647f254..bcb2910a1 100644
--- a/domains/health/Americas declining life expectancy is driven by deaths of despair concentrated in populations and regions most damaged by economic restructuring since the 1980s.md	
+++ b/domains/health/Americas declining life expectancy is driven by deaths of despair concentrated in populations and regions most damaged by economic restructuring since the 1980s.md	
@@ -6,8 +6,16 @@ confidence: proven
 source: Architectural Investing, Ch. Epidemiological Transition; JAMA 2019
 created: 2026-02-28
 related_claims: ["cvd-mortality-stagnation-affects-all-income-levels-indicating-structural-system-failure", "us-cardiovascular-mortality-gains-reversing-after-decades-of-improvement-across-major-conditions", "cvd-stagnation-drives-us-life-expectancy-plateau-3-11x-more-than-drug-deaths", "us-healthspan-declining-while-lifespan-recovers-creating-divergence", "us-healthspan-lifespan-gap-largest-globally-despite-highest-spending", "us-hypertension-mortality-doubled-2000-2019-while-treatment-control-stagnated-structural-access-failure"]
-related: ["hypertension-related-cvd-mortality-doubled-2000-2023-despite-available-treatment-indicating-behavioral-sdoh-failure", "after a threshold of material development relative deprivation replaces absolute deprivation as the primary driver of health outcomes", "Americas declining life expectancy is driven by deaths of despair concentrated in populations and regions most damaged by economic restructuring since the 1980s"]
-reweave_edges: ["hypertension-related-cvd-mortality-doubled-2000-2023-despite-available-treatment-indicating-behavioral-sdoh-failure|related|2026-03-31", "after a threshold of material development relative deprivation replaces absolute deprivation as the primary driver of health outcomes|related|2026-04-17"]
+related:
+- hypertension-related-cvd-mortality-doubled-2000-2023-despite-available-treatment-indicating-behavioral-sdoh-failure
+- after a threshold of material development relative deprivation replaces absolute deprivation as the primary driver of health outcomes
+- Americas declining life expectancy is driven by deaths of despair concentrated in populations and regions most damaged by economic restructuring since the 1980s
+reweave_edges:
+- hypertension-related-cvd-mortality-doubled-2000-2023-despite-available-treatment-indicating-behavioral-sdoh-failure|related|2026-03-31
+- after a threshold of material development relative deprivation replaces absolute deprivation as the primary driver of health outcomes|related|2026-04-17
+supports:
+- Economic downturns reduce pollution-related mortality primarily in elderly populations through air quality improvement while simultaneously increasing deaths of despair among working-age populations
+- US avoidable mortality increased in all 50 states from 2009-2019 while declining in most high-income countries, with health spending structurally decoupled from outcomes within the US but not in peer nations
 ---
 
 # Americas declining life expectancy is driven by deaths of despair concentrated in populations and regions most damaged by economic restructuring since the 1980s
@@ -65,4 +73,4 @@ Topics:
 
 **Source:** Papanicolas et al., JAMA Internal Medicine 2025
 
-Drug-related deaths contributed 71.1% of the increase in preventable avoidable deaths from external causes during 2009-2019, providing precise quantification of the deaths-of-despair mechanism's contribution to US mortality divergence. The study shows this operated across all 50 states with West Virginia experiencing the worst increase (+99.6 per 100,000) while even the best-performing state (New York, -4.9) could not escape the broader deterioration pattern.
+Drug-related deaths contributed 71.1% of the increase in preventable avoidable deaths from external causes during 2009-2019, providing precise quantification of the deaths-of-despair mechanism's contribution to US mortality divergence. The study shows this operated across all 50 states with West Virginia experiencing the worst increase (+99.6 per 100,000) while even the best-performing state (New York, -4.9) could not escape the broader deterioration pattern.
\ No newline at end of file
diff --git a/domains/health/clinical-ai-upskilling-requires-deliberate-educational-design-not-passive-exposure.md b/domains/health/clinical-ai-upskilling-requires-deliberate-educational-design-not-passive-exposure.md
index d212e887f..32040a35e 100644
--- a/domains/health/clinical-ai-upskilling-requires-deliberate-educational-design-not-passive-exposure.md
+++ b/domains/health/clinical-ai-upskilling-requires-deliberate-educational-design-not-passive-exposure.md
@@ -10,10 +10,18 @@ agent: vida
 sourced_from: health/2026-04-25-arise-state-of-clinical-ai-2026-report.md
 scope: structural
 sourcer: ARISE Network (Stanford-Harvard)
-challenges: ["ai-micro-learning-loop-creates-durable-upskilling-through-review-confirm-override-cycle"]
-related: ["human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs", "ai-micro-learning-loop-creates-durable-upskilling-through-review-confirm-override-cycle", "optional-use-ai-deployment-preserves-independent-clinical-judgment-preventing-automation-bias-pathway"]
+challenges:
+- ai-micro-learning-loop-creates-durable-upskilling-through-review-confirm-override-cycle
+related:
+- human-in-the-loop clinical AI degrades to worse-than-AI-alone because physicians both de-skill from reliance and introduce errors when overriding correct outputs
+- ai-micro-learning-loop-creates-durable-upskilling-through-review-confirm-override-cycle
+- optional-use-ai-deployment-preserves-independent-clinical-judgment-preventing-automation-bias-pathway
+supports:
+- Clinical AI human-first reasoning prevents never-skilling through pedagogical sequencing where trainees generate differential diagnoses before AI consultation
+reweave_edges:
+- Clinical AI human-first reasoning prevents never-skilling through pedagogical sequencing where trainees generate differential diagnoses before AI consultation|supports|2026-04-27
 ---
 
 # Clinical AI upskilling requires deliberate educational mechanisms and workflow design rather than occurring automatically from AI exposure
 
-The ARISE 2026 report challenges the assumption that AI assistance automatically produces upskilling through time liberation. While the report confirms that 'current AI applications function primarily as assistants rather than autonomous agents, offering an opportunity for upskilling by liberating clinicians from repetitive administrative burdens,' it immediately qualifies this with a critical caveat: 'Realizing this benefit requires deliberate educational mechanisms.' The report explicitly states that 'upskilling does not happen automatically' and that 'maintaining clinical excellence requires a shift in training paradigms, emphasizing critical oversight where human reasoning validates AI outputs.' This finding directly challenges passive upskilling narratives by establishing that the mere presence of AI tools and freed physician time is insufficient—upskilling requires intentional curriculum design, workflow restructuring, and explicit training in AI oversight. The report's emphasis on 'deliberate' mechanisms and 'shift in training paradigms' indicates that current medical education and practice environments are NOT structured to convert AI assistance into skill development. This qualification is essential for evaluating upskilling claims: the potential exists, but realization depends on institutional design choices that are not yet standard practice.
+The ARISE 2026 report challenges the assumption that AI assistance automatically produces upskilling through time liberation. While the report confirms that 'current AI applications function primarily as assistants rather than autonomous agents, offering an opportunity for upskilling by liberating clinicians from repetitive administrative burdens,' it immediately qualifies this with a critical caveat: 'Realizing this benefit requires deliberate educational mechanisms.' The report explicitly states that 'upskilling does not happen automatically' and that 'maintaining clinical excellence requires a shift in training paradigms, emphasizing critical oversight where human reasoning validates AI outputs.' This finding directly challenges passive upskilling narratives by establishing that the mere presence of AI tools and freed physician time is insufficient—upskilling requires intentional curriculum design, workflow restructuring, and explicit training in AI oversight. The report's emphasis on 'deliberate' mechanisms and 'shift in training paradigms' indicates that current medical education and practice environments are NOT structured to convert AI assistance into skill development. This qualification is essential for evaluating upskilling claims: the potential exists, but realization depends on institutional design choices that are not yet standard practice.
\ No newline at end of file
diff --git a/domains/health/glp1-receptor-agonists-provide-cardiovascular-benefits-through-weight-independent-mechanisms.md b/domains/health/glp1-receptor-agonists-provide-cardiovascular-benefits-through-weight-independent-mechanisms.md
index 6c52915ad..05717c546 100644
--- a/domains/health/glp1-receptor-agonists-provide-cardiovascular-benefits-through-weight-independent-mechanisms.md
+++ b/domains/health/glp1-receptor-agonists-provide-cardiovascular-benefits-through-weight-independent-mechanisms.md
@@ -14,9 +14,11 @@ supports:
 - GLP-1 receptor agonism provides weight-independent cardioprotective benefits in HFpEF through attenuated cardiac fibrosis and reverse lipid transport
 related:
 - acc-2025-distinguishes-glp1-symptom-improvement-from-mortality-reduction-in-hfpef
+- GLP-1 receptor agonist weight loss and side effects are partially genetically determined with GLP1R and GIPR variants predicting 6-20% weight loss range and up to 14.8-fold variation in tirzepatide-specific vomiting risk
 reweave_edges:
 - acc-2025-distinguishes-glp1-symptom-improvement-from-mortality-reduction-in-hfpef|related|2026-04-12
 - GLP-1 receptor agonism provides weight-independent cardioprotective benefits in HFpEF through attenuated cardiac fibrosis and reverse lipid transport|supports|2026-04-12
+- GLP-1 receptor agonist weight loss and side effects are partially genetically determined with GLP1R and GIPR variants predicting 6-20% weight loss range and up to 14.8-fold variation in tirzepatide-specific vomiting risk|related|2026-04-27
 ---
 
 # GLP-1 receptor agonists provide cardiovascular benefits through weight-independent mechanisms including direct cardiac GLP-1R signaling which explains why semaglutide outperforms tirzepatide in MACE reduction despite inferior weight loss
diff --git a/domains/health/semaglutide-outperforms-tirzepatide-cardiovascular-outcomes-despite-inferior-weight-loss-suggesting-glp1r-specific-cardiac-mechanism.md b/domains/health/semaglutide-outperforms-tirzepatide-cardiovascular-outcomes-despite-inferior-weight-loss-suggesting-glp1r-specific-cardiac-mechanism.md
index d74fd8f07..31041f11b 100644
--- a/domains/health/semaglutide-outperforms-tirzepatide-cardiovascular-outcomes-despite-inferior-weight-loss-suggesting-glp1r-specific-cardiac-mechanism.md
+++ b/domains/health/semaglutide-outperforms-tirzepatide-cardiovascular-outcomes-despite-inferior-weight-loss-suggesting-glp1r-specific-cardiac-mechanism.md
@@ -19,8 +19,10 @@ reweave_edges:
 - Semaglutide produces superior cardiovascular outcomes compared to tirzepatide despite achieving less weight loss because GLP-1 receptor-specific cardiac mechanisms operate independently of weight reduction|supports|2026-04-10
 - GLP-1 receptor agonists provide cardiovascular benefits through weight-independent mechanisms including direct cardiac GLP-1R signaling which explains why semaglutide outperforms tirzepatide in MACE reduction despite inferior weight loss|supports|2026-04-12
 - Semaglutide produces large-effect-size reductions in alcohol consumption and craving through VTA dopamine reward circuit suppression|related|2026-04-25
+- GLP-1 receptor agonist weight loss and side effects are partially genetically determined with GLP1R and GIPR variants predicting 6-20% weight loss range and up to 14.8-fold variation in tirzepatide-specific vomiting risk|related|2026-04-27
 related:
 - Semaglutide produces large-effect-size reductions in alcohol consumption and craving through VTA dopamine reward circuit suppression
+- GLP-1 receptor agonist weight loss and side effects are partially genetically determined with GLP1R and GIPR variants predicting 6-20% weight loss range and up to 14.8-fold variation in tirzepatide-specific vomiting risk
 ---
 
 # Semaglutide achieves 29-43 percent lower major adverse cardiovascular event rates compared to tirzepatide despite tirzepatide's superior weight loss suggesting a GLP-1 receptor-specific cardioprotective mechanism independent of weight reduction
diff --git a/domains/internet-finance/bipartisan-prediction-market-legislation-threatens-cftc-preemption-through-congressional-redefinition.md b/domains/internet-finance/bipartisan-prediction-market-legislation-threatens-cftc-preemption-through-congressional-redefinition.md
index 4810a4bb6..b84d8ca75 100644
--- a/domains/internet-finance/bipartisan-prediction-market-legislation-threatens-cftc-preemption-through-congressional-redefinition.md
+++ b/domains/internet-finance/bipartisan-prediction-market-legislation-threatens-cftc-preemption-through-congressional-redefinition.md
@@ -10,8 +10,21 @@ agent: rio
 sourced_from: internet-finance/2026-03-23-curtis-schiff-prediction-markets-gambling-act.md
 scope: structural
 sourcer: MultiState
-challenges: ["cftc-licensed-dcm-preemption-protects-centralized-prediction-markets-but-not-decentralized-governance-markets"]
-related: ["futarchy-governed entities are structurally not securities because prediction market participation replaces the concentrated promoter effort that the Howey test requires", "cftc-licensed-dcm-preemption-protects-centralized-prediction-markets-but-not-decentralized-governance-markets", "futarchy-governance-markets-risk-regulatory-capture-by-anti-gambling-frameworks-because-the-event-betting-and-organizational-governance-use-cases-are-conflated-in-current-policy-discourse", "congressional-insider-trading-legislation-for-prediction-markets-treats-them-as-financial-instruments-not-gambling-strengthening-dcm-regulatory-legitimacy", "prediction-markets-face-democratic-legitimacy-gap-despite-regulatory-approval", "prediction-markets-face-political-sustainability-risk-from-gambling-perception-despite-legal-defensibility", "bipartisan-prediction-market-legislation-threatens-cftc-preemption-through-congressional-redefinition", "dcm-field-preemption-protects-all-contracts-on-registered-platforms-regardless-of-type"]
+challenges:
+- cftc-licensed-dcm-preemption-protects-centralized-prediction-markets-but-not-decentralized-governance-markets
+related:
+- futarchy-governed entities are structurally not securities because prediction market participation replaces the concentrated promoter effort that the Howey test requires
+- cftc-licensed-dcm-preemption-protects-centralized-prediction-markets-but-not-decentralized-governance-markets
+- futarchy-governance-markets-risk-regulatory-capture-by-anti-gambling-frameworks-because-the-event-betting-and-organizational-governance-use-cases-are-conflated-in-current-policy-discourse
+- congressional-insider-trading-legislation-for-prediction-markets-treats-them-as-financial-instruments-not-gambling-strengthening-dcm-regulatory-legitimacy
+- prediction-markets-face-democratic-legitimacy-gap-despite-regulatory-approval
+- prediction-markets-face-political-sustainability-risk-from-gambling-perception-despite-legal-defensibility
+- bipartisan-prediction-market-legislation-threatens-cftc-preemption-through-congressional-redefinition
+- dcm-field-preemption-protects-all-contracts-on-registered-platforms-regardless-of-type
+supports:
+- Bipartisan state AG coalition of 38 jurisdictions signals near-consensus government opposition to CFTC prediction market preemption through federalism arguments that transcend partisan alignment
+reweave_edges:
+- Bipartisan state AG coalition of 38 jurisdictions signals near-consensus government opposition to CFTC prediction market preemption through federalism arguments that transcend partisan alignment|supports|2026-04-27
 ---
 
 # Bipartisan Senate legislation to reclassify prediction market sports contracts as gambling threatens CFTC preemption through Congressional redefinition rather than judicial interpretation
@@ -30,4 +43,4 @@ Tribal gaming industry ($40B+ annual revenue) represents a new congressional pre
 
 **Source:** Yogonet International, April 20 2026
 
-Tribal gaming coalition adds federal statutory dimension (IGRA) to congressional pressure beyond state-federal preemption fight. Tribes have treaty protections and bipartisan congressional allies, creating legislative fix pathway that state AGs alone cannot access.
+Tribal gaming coalition adds federal statutory dimension (IGRA) to congressional pressure beyond state-federal preemption fight. Tribes have treaty protections and bipartisan congressional allies, creating legislative fix pathway that state AGs alone cannot access.
\ No newline at end of file
diff --git a/domains/internet-finance/third-circuit-ruling-creates-first-federal-appellate-precedent-for-cftc-preemption-of-state-gambling-laws.md b/domains/internet-finance/third-circuit-ruling-creates-first-federal-appellate-precedent-for-cftc-preemption-of-state-gambling-laws.md
index 24c1fa7e7..2767348b9 100644
--- a/domains/internet-finance/third-circuit-ruling-creates-first-federal-appellate-precedent-for-cftc-preemption-of-state-gambling-laws.md
+++ b/domains/internet-finance/third-circuit-ruling-creates-first-federal-appellate-precedent-for-cftc-preemption-of-state-gambling-laws.md
@@ -10,9 +10,23 @@ agent: rio
 scope: structural
 sourcer: Third Circuit Court of Appeals
 related_claims: ["[[cftc-licensed-dcm-preemption-protects-centralized-prediction-markets-but-not-decentralized-governance-markets]]", "[[futarchy-governed entities are structurally not securities because prediction market participation replaces the concentrated promoter effort that the Howey test requires]]"]
-supports: ["CFTC-licensed DCM preemption protects centralized prediction markets from state gambling law but leaves decentralized governance markets legally exposed because they cannot access the DCM licensing pathway", "executive-branch-offensive-litigation-creates-preemption-through-simultaneous-multi-state-suits-not-defensive-case-law", "Prediction market SCOTUS cert is likely by early 2027 because three-circuit litigation pattern creates formal split by summer 2026 and 34-state amicus participation signals federalism stakes justify review"]
-reweave_edges: ["CFTC-licensed DCM preemption protects centralized prediction markets from state gambling law but leaves decentralized governance markets legally exposed because they cannot access the DCM licensing pathway|supports|2026-04-17", "Executive branch offensive litigation creates preemption through simultaneous multi-state suits not defensive case-law|supports|2026-04-18", "Prediction market SCOTUS cert is likely by early 2027 because three-circuit litigation pattern creates formal split by summer 2026 and 34-state amicus participation signals federalism stakes justify review|supports|2026-04-19"]
-related: ["third-circuit-ruling-creates-first-federal-appellate-precedent-for-cftc-preemption-of-state-gambling-laws", "prediction-market-scotus-cert-likely-by-early-2027-because-three-circuit-litigation-pattern-creates-formal-split-by-summer-2026-and-34-state-amicus-participation-signals-federalism-stakes-justify-review", "cftc-licensed-dcm-preemption-protects-centralized-prediction-markets-but-not-decentralized-governance-markets", "dcm-field-preemption-protects-all-contracts-on-registered-platforms-regardless-of-type", "cftc-gaming-classification-silence-signals-rule-40-11-structural-contradiction", "rule-40-11-paradox-creates-theory-level-circuit-split-on-cftc-preemption"]
+supports:
+- CFTC-licensed DCM preemption protects centralized prediction markets from state gambling law but leaves decentralized governance markets legally exposed because they cannot access the DCM licensing pathway
+- executive-branch-offensive-litigation-creates-preemption-through-simultaneous-multi-state-suits-not-defensive-case-law
+- Prediction market SCOTUS cert is likely by early 2027 because three-circuit litigation pattern creates formal split by summer 2026 and 34-state amicus participation signals federalism stakes justify review
+reweave_edges:
+- CFTC-licensed DCM preemption protects centralized prediction markets from state gambling law but leaves decentralized governance markets legally exposed because they cannot access the DCM licensing pathway|supports|2026-04-17
+- Executive branch offensive litigation creates preemption through simultaneous multi-state suits not defensive case-law|supports|2026-04-18
+- Prediction market SCOTUS cert is likely by early 2027 because three-circuit litigation pattern creates formal split by summer 2026 and 34-state amicus participation signals federalism stakes justify review|supports|2026-04-19
+related:
+- third-circuit-ruling-creates-first-federal-appellate-precedent-for-cftc-preemption-of-state-gambling-laws
+- prediction-market-scotus-cert-likely-by-early-2027-because-three-circuit-litigation-pattern-creates-formal-split-by-summer-2026-and-34-state-amicus-participation-signals-federalism-stakes-justify-review
+- cftc-licensed-dcm-preemption-protects-centralized-prediction-markets-but-not-decentralized-governance-markets
+- dcm-field-preemption-protects-all-contracts-on-registered-platforms-regardless-of-type
+- cftc-gaming-classification-silence-signals-rule-40-11-structural-contradiction
+- rule-40-11-paradox-creates-theory-level-circuit-split-on-cftc-preemption
+challenges:
+- 9th Circuit Kalshi ruling functions as coordinating precedent for multiple parallel cases amplifying its regulatory impact beyond the Nevada-specific dispute
 ---
 
 # Third Circuit ruling creates first federal appellate precedent for CFTC preemption of state gambling laws making Supreme Court review near-certain
@@ -51,4 +65,4 @@ The 3rd Circuit precedent is now one side of an emerging circuit split with the
 
 **Source:** Nevada Current, Bloomberg Law, April 2026
 
-3rd Circuit ruled April 7, 2026 FOR Kalshi (CEA preempts state gambling laws). 9th Circuit panel leaned AGAINST Kalshi at April 16 oral arguments, with ruling expected June-August 2026. This creates imminent circuit split with SCOTUS cert petition likely fall 2026 and argument spring 2027 at earliest.
+3rd Circuit ruled April 7, 2026 FOR Kalshi (CEA preempts state gambling laws). 9th Circuit panel leaned AGAINST Kalshi at April 16 oral arguments, with ruling expected June-August 2026. This creates imminent circuit split with SCOTUS cert petition likely fall 2026 and argument spring 2027 at earliest.
\ No newline at end of file