vida: extract claims from 2026-05-08-glp1-cocaine-use-disorder-phase2-recruiting-2025

- Source: inbox/queue/2026-05-08-glp1-cocaine-use-disorder-phase2-recruiting-2025.md
- Domain: health
- Claims: 0, Entities: 2
- Enrichments: 1
- Extracted by: pipeline ingest (OpenRouter anthropic/claude-sonnet-4.5)

Pentagon-Agent: Vida <PIPELINE>

entities/health/nct-semaglutide-cud-phase2-cbt.md

@@ -0,0 +1,22 @@
+# Semaglutide + CBT for Cocaine Use Disorder (Phase 2)
+
+**Type:** Clinical trial  
+**Phase:** 2  
+**Status:** Recruiting (as of May 2026)  
+**Intervention:** Semaglutide combined with cognitive behavioral therapy (CBT)  
+**Population:** Adults with diagnosed cocaine use disorder and BMI ≥25  
+**Primary objective:** Reduce cocaine cravings and use  
+**Registry:** withpower.com/trial/phase-2-cocaine-related-disorders-10-2025
+
+## Timeline
+
+- **2025-10** — Trial opened for recruitment
+- **2026-05** — Actively recruiting participants
+
+## Context
+
+This trial follows the All of Us observational finding (Abegaz et al., March 2026) showing 75% lower odds of cocaine use disorder in GLP-1 users (OR=0.25). Cocaine use disorder has no FDA-approved pharmacotherapy, making this a high-priority unmet need. The trial combines semaglutide with CBT, reflecting the behavioral-biological integration model seen in other GLP-1 SUD trials.
+
+## Expected Results
+
+Phase 2 results anticipated 2027-2028.

entities/health/nct-semaglutide-cud-phase2-hiv.md

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+# Semaglutide for Cocaine Use Disorder in HIV Cohort (Phase 2)
+
+**Type:** Clinical trial  
+**Phase:** 2  
+**Status:** Recruiting (as of May 2026)  
+**Intervention:** Semaglutide vs. placebo  
+**Population:** Adults with cocaine use disorder, with and without HIV infection  
+**Primary objective:** Safety and effectiveness of semaglutide for CUD  
+**Special population rationale:** High CUD prevalence in HIV+ individuals; dual metabolic and addiction benefits  
+**Registry:** withpower.com/trial/phase-2-human-immunodeficiency-virus-hiv-infections-2-2025
+
+## Timeline
+
+- **2025-02** — Trial opened for recruitment
+- **2026-05** — Actively recruiting participants
+
+## Context
+
+This trial targets a high-need population where CUD prevalence is elevated and metabolic complications are common. The HIV-specific design provides real-world justification for off-label use even before CUD-specific approval. Follows All of Us observational signal (OR=0.25 for CUD in GLP-1 users).
+
+## Expected Results
+
+Phase 2 results anticipated 2027-2028.

inbox/archive/health/2026-05-08-glp1-cocaine-use-disorder-phase2-recruiting-2025.md

@@ -7,10 +7,13 @@ date: 2025-01-01
 domain: health
 secondary_domains: []
 format: article
-status: unprocessed
+status: processed
+processed_by: vida
+processed_date: 2026-05-08
 priority: medium
 tags: [GLP-1, cocaine use disorder, substance use disorder, semaglutide, Phase 2 trial, addiction medicine, CUD]
 intake_tier: research-task
+extraction_model: "anthropic/claude-sonnet-4.5"
 ---
 
 ## Content