diff --git a/domains/health/glp-1-multi-organ-protection-creates-compounding-value-across-kidney-cardiovascular-and-metabolic-endpoints.md b/domains/health/glp-1-multi-organ-protection-creates-compounding-value-across-kidney-cardiovascular-and-metabolic-endpoints.md index 1222d36b..8dab4f1b 100644 --- a/domains/health/glp-1-multi-organ-protection-creates-compounding-value-across-kidney-cardiovascular-and-metabolic-endpoints.md +++ b/domains/health/glp-1-multi-organ-protection-creates-compounding-value-across-kidney-cardiovascular-and-metabolic-endpoints.md @@ -30,6 +30,12 @@ For value-based care models and capitated payers, this multi-organ protection cr - Nature Medicine: additive benefits with SGLT2 inhibitors - First GLP-1 to receive FDA indication for CKD in T2D patients + +### Additional Evidence (extend) +*Source: [[2025-12-23-jama-cardiology-select-hospitalization-analysis]] | Added: 2026-03-16* + +SELECT trial exploratory analysis (N=17,604, median 41.8 months) shows semaglutide reduces ALL-CAUSE hospitalizations by 10% (18.3 vs 20.4 per 100 patient-years, P<.001) and total hospital days by 11% (157.2 vs 176.2 days per 100 patient-years, P=.01). Critically, benefits extended beyond cardiovascular causes to total hospitalization burden, suggesting systemic effects across multiple organ systems. + --- Relevant Notes: diff --git a/inbox/archive/2025-12-23-jama-cardiology-select-hospitalization-analysis.md b/inbox/archive/2025-12-23-jama-cardiology-select-hospitalization-analysis.md index 340f1a58..771f4942 100644 --- a/inbox/archive/2025-12-23-jama-cardiology-select-hospitalization-analysis.md +++ b/inbox/archive/2025-12-23-jama-cardiology-select-hospitalization-analysis.md @@ -7,9 +7,13 @@ date: 2025-12-23 domain: health secondary_domains: [internet-finance] format: paper -status: unprocessed +status: enrichment priority: high tags: [glp-1, semaglutide, hospitalization, cardiovascular, SELECT-trial, cost-offset] +processed_by: vida +processed_date: 2026-03-16 +enrichments_applied: ["glp-1-multi-organ-protection-creates-compounding-value-across-kidney-cardiovascular-and-metabolic-endpoints.md"] +extraction_model: "anthropic/claude-sonnet-4.5" --- ## Content @@ -36,3 +40,12 @@ Median age 61.0 years; 27.7% female; median BMI 32.1. PRIMARY CONNECTION: [[the healthcare attractor state is a prevention-first system where aligned payment continuous monitoring and AI-augmented care delivery create a flywheel that profits from health rather than sickness]] WHY ARCHIVED: All-cause hospitalization reduction is the most economically relevant outcome for risk-bearing payers and the strongest evidence that GLP-1s could be cost-saving under capitation EXTRACTION HINT: Focus on the all-cause hospitalization signal (not just CV) — this is what makes GLP-1s relevant to VBC economics beyond cardiology + + +## Key Facts +- SELECT trial: N=17,604 patients with obesity and established CVD, median follow-up 41.8 months +- Median age 61.0 years, 27.7% female, median BMI 32.1 +- Total hospitalizations: 18.3 vs 20.4 per 100 patient-years (mean ratio 0.90, P<.001) +- Hospitalizations for serious adverse events: 15.2 vs 17.1 per 100 patient-years (mean ratio 0.89, P<.001) +- Days hospitalized: 157.2 vs 176.2 per 100 patient-years (rate ratio 0.89, P=.01) +- Published in JAMA Cardiology as prespecified exploratory analysis