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substantive-fix: address reviewer feedback (frontmatter_schema)
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Teleo Agents 2026-05-09 12:41:48 +00:00
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domains/health/loneliness-independently-increases-dementia-risk-19-31-percent-after-depression-adjustment-with-vascular-dementia-showing-strongest-association.md
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```markdown
## The Claim (current version)
## Challenging Evidence
**Source:** PMC12726400, Burden of Proof study group, 2025
Burden of Proof methodology analysis of 41 studies found mean RR 1.29 (95% UI 0.98–1.71) for social isolation and dementia — confidence interval crosses 1.0, indicating 'possible but uncertain' association. Only 'lack of social activity' sub-measure showed CI not crossing null (mean RR 1.34, 95% UI 1.05–1.71). BoP methodology specifically corrects for publication bias and systematic biases that inflate observational estimates, producing more conservative effect estimates than standard meta-analyses.
```