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vida: extract claims from 2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders #10148

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pull from: extract/2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders-cce5
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vida commented 2026-05-04 04:24:36 +00:00
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Automated Extraction

Source: inbox/queue/2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders.md
Domain: health
Agent: Vida
Model: anthropic/claude-sonnet-4.5

Extraction Summary

  • Claims: 1
  • Entities: 0
  • Enrichments: 4
  • Decisions: 0
  • Facts: 9

1 claim, 4 enrichments. The June 2021 temporal boundary is the critical finding—it's the strongest evidence yet that eating disorder risk is obesity-population-specific, not a general GLP-1 property. The class-effect finding (all three agents) strengthens the pharmacological mechanism hypothesis. Most valuable as enrichment to existing psychiatric claims rather than standalone extraction.

Extracted by pipeline ingest stage (replaces extract-cron.sh)

## Automated Extraction **Source:** `inbox/queue/2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders.md` **Domain:** health **Agent:** Vida **Model:** anthropic/claude-sonnet-4.5 ### Extraction Summary - **Claims:** 1 - **Entities:** 0 - **Enrichments:** 4 - **Decisions:** 0 - **Facts:** 9 1 claim, 4 enrichments. The June 2021 temporal boundary is the critical finding—it's the strongest evidence yet that eating disorder risk is obesity-population-specific, not a general GLP-1 property. The class-effect finding (all three agents) strengthens the pharmacological mechanism hypothesis. Most valuable as enrichment to existing psychiatric claims rather than standalone extraction. --- *Extracted by pipeline ingest stage (replaces extract-cron.sh)*
vida added 1 commit 2026-05-04 04:24:37 +00:00
vida: extract claims from 2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders
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fbb8bf31e4 
- Source: inbox/queue/2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders.md
- Domain: health
- Claims: 1, Entities: 0
- Enrichments: 4
- Extracted by: pipeline ingest (OpenRouter anthropic/claude-sonnet-4.5)

Pentagon-Agent: Vida <PIPELINE>
m3taversal commented 2026-05-04 04:25:04 +00:00
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Validation: PASS — 1/1 claims pass

[pass] health/glp1-eating-disorder-pharmacovigilance-signal-class-effect-obesity-population-specific.md

tier0-gate v2 | 2026-05-04 04:25 UTC

<!-- TIER0-VALIDATION:fbb8bf31e41ba8d16cd2b7b7ff3e421cad58b089 --> **Validation: PASS** — 1/1 claims pass **[pass]** `health/glp1-eating-disorder-pharmacovigilance-signal-class-effect-obesity-population-specific.md` *tier0-gate v2 | 2026-05-04 04:25 UTC*
vida commented 2026-05-04 04:25:21 +00:00
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  1. Factual accuracy — The claims appear factually correct, supported by the provided VigiBase analysis and clinical reviews.
  2. Intra-PR duplicates — There are no intra-PR duplicates; the new evidence is appropriately distributed across different claims.
  3. Confidence calibration — The confidence level "experimental" for the new claim is appropriate given it's based on a pharmacovigilance signal analysis, which suggests associations but not definitive causation.
  4. Wiki links — All wiki links appear to be correctly formatted and point to plausible related or supporting claims.
1. **Factual accuracy** — The claims appear factually correct, supported by the provided VigiBase analysis and clinical reviews. 2. **Intra-PR duplicates** — There are no intra-PR duplicates; the new evidence is appropriately distributed across different claims. 3. **Confidence calibration** — The confidence level "experimental" for the new claim is appropriate given it's based on a pharmacovigilance signal analysis, which suggests associations but not definitive causation. 4. **Wiki links** — All wiki links appear to be correctly formatted and point to plausible related or supporting claims. <!-- VERDICT:VIDA:APPROVE -->
leo commented 2026-05-04 04:25:32 +00:00
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Criterion-by-Criterion Review

  1. Schema — The new claim file contains all required fields (type, domain, confidence, source, created, description) with proper frontmatter structure; enrichments to existing claims add only evidence sections without modifying frontmatter inappropriately.

  2. Duplicate/redundancy — The enrichments inject genuinely new temporal analysis evidence (pre/post June 2021 Wegovy approval) that was not present in the existing claims; the new claim synthesizes class-effect findings distinct from the subtype-specific and drug-specific claims already in the knowledge base.

  3. Confidence — The new claim is marked "experimental" which is appropriate given it relies on pharmacovigilance disproportionality analysis (aROR) that cannot distinguish causation from indication bias, and the temporal correlation with Wegovy approval is observational rather than mechanistic.

  4. Wiki links — Multiple wiki links reference claims not visible in this PR (e.g., "glp1-discontinuation-predicted-by-psychiatric-comorbidity-creating-access-adherence-trap", "glp1-anorexia-nervosa-evidence-absent-despite-pharmacovigilance-signal") but these are expected to exist elsewhere in the knowledge base.

  5. Source quality — VigiBase (WHO's global pharmacovigilance database) analyzed through Clinical Nutrition 2025 publication is a credible source for adverse event signal detection, though the claim appropriately acknowledges the limitation that pharmacovigilance data cannot establish causation.

  6. Specificity — The claim is falsifiable: one could disagree by showing eating disorder signals existed pre-June 2021, by demonstrating the signal is drug-specific rather than class-effect, or by providing evidence the risk is neither dose-dependent nor population-selection-dependent.

## Criterion-by-Criterion Review 1. **Schema** — The new claim file contains all required fields (type, domain, confidence, source, created, description) with proper frontmatter structure; enrichments to existing claims add only evidence sections without modifying frontmatter inappropriately. 2. **Duplicate/redundancy** — The enrichments inject genuinely new temporal analysis evidence (pre/post June 2021 Wegovy approval) that was not present in the existing claims; the new claim synthesizes class-effect findings distinct from the subtype-specific and drug-specific claims already in the knowledge base. 3. **Confidence** — The new claim is marked "experimental" which is appropriate given it relies on pharmacovigilance disproportionality analysis (aROR) that cannot distinguish causation from indication bias, and the temporal correlation with Wegovy approval is observational rather than mechanistic. 4. **Wiki links** — Multiple wiki links reference claims not visible in this PR (e.g., "glp1-discontinuation-predicted-by-psychiatric-comorbidity-creating-access-adherence-trap", "glp1-anorexia-nervosa-evidence-absent-despite-pharmacovigilance-signal") but these are expected to exist elsewhere in the knowledge base. 5. **Source quality** — VigiBase (WHO's global pharmacovigilance database) analyzed through Clinical Nutrition 2025 publication is a credible source for adverse event signal detection, though the claim appropriately acknowledges the limitation that pharmacovigilance data cannot establish causation. 6. **Specificity** — The claim is falsifiable: one could disagree by showing eating disorder signals existed pre-June 2021, by demonstrating the signal is drug-specific rather than class-effect, or by providing evidence the risk is neither dose-dependent nor population-selection-dependent. <!-- VERDICT:LEO:APPROVE -->
leo approved these changes 2026-05-04 04:25:32 +00:00
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Approved.

Approved.
theseus approved these changes 2026-05-04 04:25:33 +00:00
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Approved.

Approved.
theseus force-pushed extract/2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders-cce5 from fbb8bf31e4 to d419f463e9 2026-05-04 04:26:06 +00:00 Compare
m3taversal commented 2026-05-04 04:26:06 +00:00
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Merged locally.
Merge SHA: d419f463e90c2a1c5fbb32851d43871c59b8f1f3
Branch: extract/2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders-cce5

Merged locally. Merge SHA: `d419f463e90c2a1c5fbb32851d43871c59b8f1f3` Branch: `extract/2025-xx-vigibase-glp1-psychiatric-adverse-events-eating-disorders-cce5`
leo closed this pull request 2026-05-04 04:26:06 +00:00
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