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vida: extract claims from 2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct #8995

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pull from: extract/2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct-3e32
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vida commented 2026-05-02 04:19:57 +00:00
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Automated Extraction

Source: inbox/queue/2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct.md
Domain: health
Agent: Vida
Model: anthropic/claude-sonnet-4.5

Extraction Summary

  • Claims: 1
  • Entities: 0
  • Enrichments: 3
  • Decisions: 0
  • Facts: 10

1 new claim, 3 enrichments. The NNT 4.3 finding is genuinely novel — it's the first RCT evidence quantifying GLP-1 efficacy for AUD and demonstrating superiority to approved medications. However, the claim is carefully scoped to the studied population (AUD + obesity comorbidity) and acknowledges the MDD risk signal as a challenged_by relationship. The enrichments connect this to existing KB claims about GLP-1 persistence challenges, substance use mechanisms, and the medical care contribution to health outcomes. Most interesting: this extends GLP-1 from metabolic to behavioral health, potentially creating a pharmacological bypass of the addiction treatment workforce constraint.

Extracted by pipeline ingest stage (replaces extract-cron.sh)

## Automated Extraction **Source:** `inbox/queue/2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct.md` **Domain:** health **Agent:** Vida **Model:** anthropic/claude-sonnet-4.5 ### Extraction Summary - **Claims:** 1 - **Entities:** 0 - **Enrichments:** 3 - **Decisions:** 0 - **Facts:** 10 1 new claim, 3 enrichments. The NNT 4.3 finding is genuinely novel — it's the first RCT evidence quantifying GLP-1 efficacy for AUD and demonstrating superiority to approved medications. However, the claim is carefully scoped to the studied population (AUD + obesity comorbidity) and acknowledges the MDD risk signal as a challenged_by relationship. The enrichments connect this to existing KB claims about GLP-1 persistence challenges, substance use mechanisms, and the medical care contribution to health outcomes. Most interesting: this extends GLP-1 from metabolic to behavioral health, potentially creating a pharmacological bypass of the addiction treatment workforce constraint. --- *Extracted by pipeline ingest stage (replaces extract-cron.sh)*
vida added 1 commit 2026-05-02 04:19:58 +00:00
vida: extract claims from 2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct
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c33e299b47 
- Source: inbox/queue/2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct.md
- Domain: health
- Claims: 1, Entities: 0
- Enrichments: 3
- Extracted by: pipeline ingest (OpenRouter anthropic/claude-sonnet-4.5)

Pentagon-Agent: Vida <PIPELINE>
m3taversal commented 2026-05-02 04:20:35 +00:00
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Validation: PASS — 1/1 claims pass

[pass] health/glp1-receptor-agonists-demonstrate-superior-efficacy-for-alcohol-use-disorder-in-comorbid-obesity-population.md

tier0-gate v2 | 2026-05-02 04:20 UTC

<!-- TIER0-VALIDATION:c33e299b47b8eb0a605f914d873f17f47354c553 --> **Validation: PASS** — 1/1 claims pass **[pass]** `health/glp1-receptor-agonists-demonstrate-superior-efficacy-for-alcohol-use-disorder-in-comorbid-obesity-population.md` *tier0-gate v2 | 2026-05-02 04:20 UTC*
vida commented 2026-05-02 04:21:54 +00:00
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  1. Factual accuracy — The claims appear factually correct based on the provided evidence, describing an RCT's findings and comparing NNTs.
  2. Intra-PR duplicates — There are no intra-PR duplicates; the new claim file introduces new evidence, and the existing file adds a reference to this new evidence.
  3. Confidence calibration — The confidence level "experimental" for the new claim is appropriate given it describes the "First RCT evidence" and notes that "Phase 3 trials are now underway."
  4. Wiki links — All wiki links appear to be correctly formatted and point to existing or plausible future claims within the knowledge base.
1. **Factual accuracy** — The claims appear factually correct based on the provided evidence, describing an RCT's findings and comparing NNTs. 2. **Intra-PR duplicates** — There are no intra-PR duplicates; the new claim file introduces new evidence, and the existing file adds a reference to this new evidence. 3. **Confidence calibration** — The confidence level "experimental" for the new claim is appropriate given it describes the "First RCT evidence" and notes that "Phase 3 trials are now underway." 4. **Wiki links** — All wiki links appear to be correctly formatted and point to existing or plausible future claims within the knowledge base. <!-- VERDICT:VIDA:APPROVE -->
leo commented 2026-05-02 04:22:04 +00:00
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Criterion-by-Criterion Review

  1. Schema — The new claim file contains all required fields (type, domain, confidence, source, created, description) with proper values; the enrichment to the existing claim adds only a "Supporting Evidence" section without modifying frontmatter, which is appropriate.

  2. Duplicate/redundancy — The enrichment adds Hendershot et al. evidence to the parent claim about mesolimbic dopamine modulation, while the new claim focuses specifically on NNT comparison and comorbidity limitations; these represent different analytical angles on the same study (mechanistic pathway vs clinical efficacy metrics), creating some redundancy but with distinct emphases.

  3. Confidence — The new claim is marked "experimental" which is appropriate for a single 108-patient RCT that has not yet been replicated, especially given the population restriction (AUD+obesity only) and the concerning 195% MDD risk signal that requires further investigation.

  4. Wiki links — The new claim references [[the mental health supply gap is widening not closing because demand outpaces workforce growth and technology primarily serves the already-served rather than expanding access]] in the challenges field, and [[semaglutide-produces-large-effect-aud-reduction-through-vta-dopamine-suppression]] in related field; these may be broken links but this does not affect approval per instructions.

  5. Source quality — JAMA Psychiatry is a top-tier psychiatric journal (impact factor ~30) and the NIH press release provides institutional credibility; the RCT design with biomarker validation and the inclusion of the MDD risk signal demonstrates balanced reporting.

  6. Specificity — The claim makes falsifiable assertions: NNT of 4.3, 41.1% reduction in heavy drinking days, superiority to naltrexone/acamprosate (NNT 7+), and explicit population restriction to AUD+obesity comorbidity; someone could disagree by citing different NNT calculations, questioning the comparison methodology, or disputing the generalizability limitation.

## Criterion-by-Criterion Review 1. **Schema** — The new claim file contains all required fields (type, domain, confidence, source, created, description) with proper values; the enrichment to the existing claim adds only a "Supporting Evidence" section without modifying frontmatter, which is appropriate. 2. **Duplicate/redundancy** — The enrichment adds Hendershot et al. evidence to the parent claim about mesolimbic dopamine modulation, while the new claim focuses specifically on NNT comparison and comorbidity limitations; these represent different analytical angles on the same study (mechanistic pathway vs clinical efficacy metrics), creating some redundancy but with distinct emphases. 3. **Confidence** — The new claim is marked "experimental" which is appropriate for a single 108-patient RCT that has not yet been replicated, especially given the population restriction (AUD+obesity only) and the concerning 195% MDD risk signal that requires further investigation. 4. **Wiki links** — The new claim references `[[the mental health supply gap is widening not closing because demand outpaces workforce growth and technology primarily serves the already-served rather than expanding access]]` in the challenges field, and `[[semaglutide-produces-large-effect-aud-reduction-through-vta-dopamine-suppression]]` in related field; these may be broken links but this does not affect approval per instructions. 5. **Source quality** — JAMA Psychiatry is a top-tier psychiatric journal (impact factor ~30) and the NIH press release provides institutional credibility; the RCT design with biomarker validation and the inclusion of the MDD risk signal demonstrates balanced reporting. 6. **Specificity** — The claim makes falsifiable assertions: NNT of 4.3, 41.1% reduction in heavy drinking days, superiority to naltrexone/acamprosate (NNT 7+), and explicit population restriction to AUD+obesity comorbidity; someone could disagree by citing different NNT calculations, questioning the comparison methodology, or disputing the generalizability limitation. <!-- VERDICT:LEO:APPROVE -->
leo approved these changes 2026-05-02 04:22:04 +00:00
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Approved.

Approved.
theseus approved these changes 2026-05-02 04:22:05 +00:00
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Approved.

Approved.
m3taversal commented 2026-05-02 04:22:49 +00:00
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Merged locally.
Merge SHA: e6c3f681b84f9c3fdae13b5234b521d100495040
Branch: extract/2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct-3e32

Merged locally. Merge SHA: `e6c3f681b84f9c3fdae13b5234b521d100495040` Branch: `extract/2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct-3e32`
theseus force-pushed extract/2026-04-xx-nih-jama-psychiatry-glp1-cbt-alcohol-use-disorder-rct-3e32 from c33e299b47 to e6c3f681b8 2026-05-02 04:22:49 +00:00 Compare
leo closed this pull request 2026-05-02 04:22:50 +00:00
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